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Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine.
Agrawal, Ira; Lim, Yong Shan; Ng, Shi-Yan; Ling, Shuo-Chien.
Afiliação
  • Agrawal I; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Tahir Foundation Building, MD1, 16-03-H, 12 Science Drive 2, Singapore, 117549, Singapore.
  • Lim YS; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ng SY; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Tahir Foundation Building, MD1, 16-03-H, 12 Science Drive 2, Singapore, 117549, Singapore.
  • Ling SC; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Tahir Foundation Building, MD1, 16-03-H, 12 Science Drive 2, Singapore, 117549, Singapore.
Transl Neurodegener ; 11(1): 48, 2022 11 07.
Article em En | MEDLINE | ID: mdl-36345044
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols. Lipids not only regulate integrity and fluidity of biological membranes, but also serve as energy storage and bioactive molecules for signaling. Causal mutations in SPTLC1 (serine palmitoyltransferase long chain subunit 1) gene within the lipogenic pathway have been identified in amyotrophic lateral sclerosis (ALS), a paralytic and fatal motor neuron disease. Furthermore, lipid dysmetabolism within the central nervous system and circulation is associated with ALS. Here, we aim to delineate the diverse roles of different lipid classes and understand how lipid dysmetabolism may contribute to ALS pathogenesis. Among the different lipids, accumulation of ceramides, arachidonic acid, and lysophosphatidylcholine is commonly emerging  as detrimental to motor neurons. We end with exploring the potential ALS therapeutics by reducing these toxic lipids.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença dos Neurônios Motores / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença dos Neurônios Motores / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2022 Tipo de documento: Article