Myelinated axon as a plastic cable regulating brain functions.
Neurosci Res
; 187: 45-51, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36347403
ABSTRACT
Each oligodendrocyte (OC) forms myelin approximately in around 10 different axons to coordinate information transfer by regulating conduction velocity in the central nervous system (CNS). In the classical view, myelin has been considered a static structure that rarely turns over under healthy conditions because myelin tightly holds axons by their laminar complex structure. However, in recent decades, the classical views of static myelin have been renewed with pioneering studies that showed plastic changes in myelin throughout life with new experiences, such as the acquisition of new motor skills and the formation of memory. These changes in myelin regulate conduction velocity to optimize the temporal pattern of neuronal circuit activity among distinct brain regions associated with skill learning and memory. Here, we introduce pioneering studies and discuss the implications of plastic myelin on neural circuits and brain function.
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Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Bainha de Mielina
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article