Inhibitors of DNA Methylation.
Adv Exp Med Biol
; 1389: 471-513, 2022.
Article
em En
| MEDLINE
| ID: mdl-36350520
ABSTRACT
DNA methylation is involved in numerous biological processes and is deregulated in human diseases. The modulation of the activity of the enzymes and proteins in charge of DNA methylation, for example, DNA methyltransferases (DNMTs), can represent a powerful strategy to alter DNA methylation patterns and restore biological processes that are aberrant in diseases. In this chapter, we present examples of inhibitors of DNMTs (DNMTi). We review their fields of application either as therapeutic molecules, for example, in cancers, cardiovascular, neurological, and infectious diseases or as bioengineering tools. Finally, novel strategies to target DNA methylation and overcome the limits of single DNMT inhibitors will be described. These strategies consist in either targeting the methyl group reader proteins rather than targeting directly DNMTs or to combine within the same molecule a DNMT inhibitor with an additional active moiety, e.g., HDAC inhibitor, to improve efficacy and lower secondary effect of such drug.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metilação de DNA
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article