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Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly.
Calder, Lesley J; Calcraft, Thomas; Hussain, Saira; Harvey, Ruth; Rosenthal, Peter B.
Afiliação
  • Calder LJ; Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, NW1 1AT, London, United Kingdom.
  • Calcraft T; Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, NW1 1AT, London, United Kingdom.
  • Hussain S; Worldwide Influenza Centre, The Francis Crick Institute, NW1 1AT, London, UK.
  • Harvey R; RNA Virus Replication Laboratory, The Francis Crick Institute, NW1 1AT, London, UK.
  • Rosenthal PB; Worldwide Influenza Centre, The Francis Crick Institute, NW1 1AT, London, UK.
Commun Biol ; 5(1): 1210, 2022 11 10.
Article em En | MEDLINE | ID: mdl-36357779
ABSTRACT
SARS-CoV-2 is a lipid-enveloped Betacoronavirus and cause of the Covid-19 pandemic. To study the three-dimensional architecture of the virus, we perform electron cryotomography (cryo-ET) on SARS-Cov-2 virions and three variants revealing particles of regular cylindrical morphology. The ribonucleoprotein particles packaging the genome in the virion interior form a dense, double layer assembly with a cylindrical shape related to the overall particle morphology. This organisation suggests structural interactions important to virus assembly.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article