SIRT1 Promotes Host Protective Immunity against <i>Toxoplasma gondii</i> by Controlling the FoxO-Autophagy Axis via the AMPK and PI3K/AKT Signalling Pathways.

Lee, Jina; Kim, Jinju; Lee, Jae-Hyung; Choi, Yong Min; Choi, Hyeonil; Cho, Hwan-Doo; Cha, Guang-Ho; Lee, Young-Ha; Jo, Eun-Kyeong; Park, Byung-Hyun; Yuk, Jae-Min

SIRT1 Promotes Host Protective Immunity against Toxoplasma gondii by Controlling the FoxO-Autophagy Axis via the AMPK and PI3K/AKT Signalling Pathways.

Lee, Jina; Kim, Jinju; Lee, Jae-Hyung; Choi, Yong Min; Choi, Hyeonil; Cho, Hwan-Doo; Cha, Guang-Ho; Lee, Young-Ha; Jo, Eun-Kyeong; Park, Byung-Hyun; Yuk, Jae-Min.

Afiliação

Lee J; Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Kim J; Infection Control Convergence Research Center, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Lee JH; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Choi YM; Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Choi H; Infection Control Convergence Research Center, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Cho HD; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Cha GH; Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Lee YH; Infection Control Convergence Research Center, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Jo EK; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Park BH; Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Yuk JM; Infection Control Convergence Research Center, College of Medicine, Chungnam National University, Daejeon 35015, Korea.

Int J Mol Sci ; 23(21)2022 Nov 05.

Article em En | MEDLINE | ID: mdl-36362370

Assuntos

Toxoplasma; Animais; Humanos; Camundongos; Proteínas Quinases Ativadas por AMP/metabolismo; Autofagia; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Sirtuína 1/genética; Toxoplasma/metabolismo; Fatores de Transcrição Forkhead/metabolismo

Palavras-chave

AMP-activated protein kinase; Class O of forkhead box transcription factors; PI3K/AKT signalling pathway; Sirtuin 1; Toxoplasma gondii; autophagy; bone-marrow-derived macrophages

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxoplasma Idioma: En Ano de publicação: 2022 Tipo de documento: Article