Molecular insights into the critical role of gallate moiety of green tea catechins in modulating prion fibrillation, cellular internalization, and neuronal toxicity.

Admane, Nikita; Srivastava, Ankit; Jamal, Salma; Sharma, Ritika; Kundu, Bishwajit; Grover, Abhinav

Admane, Nikita; Srivastava, Ankit; Jamal, Salma; Sharma, Ritika; Kundu, Bishwajit; Grover, Abhinav.

Afiliação

Admane N; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Srivastava A; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Jamal S; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Sharma R; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
Kundu B; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address: bkundu@bioschool.iitd.ac.in.
Grover A; School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: abhinavgr@gmail.com.

Int J Biol Macromol ; 223(Pt A): 755-765, 2022 Dec 31.

Article em En | MEDLINE | ID: mdl-36368361

Assuntos

Catequina; Doenças Priônicas; Príons; Humanos; Príons/química; Proteínas Priônicas/química; Chá; Simulação de Acoplamento Molecular; Catequina/farmacologia

Palavras-chave

Amyloid; Atomic force microscopy; Catechin; Fibril; Gallate; Neuronal toxicity; Oligomer; Prion; Transmissible spongiform encephalopathies

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Catequina / Doenças Priônicas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Catequina / Doenças Priônicas Idioma: En Ano de publicação: 2022 Tipo de documento: Article