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Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes).
Horie, Yoshifumi; Yamagishi, Takahiro; Yamamoto, Jun; Suzuki, Mayumi; Onishi, Yuta; Chiba, Takashi; Miyagawa, Shinichi; Lange, Anke; Tyler, Charles R; Okamura, Hideo; Iguchi, Taisen.
Afiliação
  • Horie Y; Research Center for Inland Seas (KURCIS), Kobe University, Fukaeminami-machi, Higashinada-ku, Kobe 658-0022, Japan. Electronic address: horie@people.kobe-u.ac.jp.
  • Yamagishi T; Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
  • Yamamoto J; Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka 421-0212, Japan.
  • Suzuki M; Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka 421-0212, Japan.
  • Onishi Y; Institute of Environmental Ecology, IDEA Consultants, Inc., Shizuoka 421-0212, Japan.
  • Chiba T; Department of Environmental and Symbiotic Science, Rakuno Gakuen University, 582 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
  • Miyagawa S; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Niijuku 6-3-1, Katsushika, Tokyo 125-8585, Japan.
  • Lange A; Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
  • Tyler CR; Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
  • Okamura H; Research Center for Inland Seas (KURCIS), Kobe University, Fukaeminami-machi, Higashinada-ku, Kobe 658-0022, Japan.
  • Iguchi T; Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
Article em En | MEDLINE | ID: mdl-36368510
Thyroid-hormone-disrupting chemicals are increasingly attracting attention because of their potential harmful effects on animal health, including on fishes. Here, we investigated the effects of exposure to the thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil (PTU) and tetrabromobisphenol A (TBBPA) on swim bladder inflation, eye development, growth, swimming performance, and the expression of thyroid-related genes in Japanese medaka (Oryzias latipes). PTU exposure resulted in reductions in eye size, growth, and swim bladder inflation, and these effects led to poorer swimming performance. These phenotypic effects were accompanied by increased expression of the thyroid-stimulating hormone subunit beta (tshß) paralog tshß-like, but there were no significant changes in expression for tshß, deiodinase 1 (dio1), deiodinase 2 (dio2), and thyroid hormone receptor alpha (trα) and beta (trß). For PTU exposure, we identified the key event (swim bladder inflation reduction) and an adverse outcome (swimming performance reduction). No significant effects from TBBPA exposure were seen on swim bladder inflation, eye development, growth, or swimming performance. However, expression of tshß-like and tshß (significantly enhanced) and trα and trß (significantly reduced) were affected by TBBPA exposure albeit not in dose-dependent manners. There were no effects of TBBPA on the expression of dio1 and dio2. We thus show that the two thyroid-hormone-disrupting chemicals PTU and TBBPA differ in their effect profiles with comparable effects on the studied phenotypes and thyroid-related gene expression to those reported in zebrafish.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oryzias Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oryzias Idioma: En Ano de publicação: 2023 Tipo de documento: Article