Real-world toxicity and effectiveness of ixazomib, lenalidomide, and dexamethasone in Korean patients with relapsed and/or refractory multiple myeloma.
Int J Hematol
; 117(2): 225-235, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36369635
ABSTRACT
BACKGROUND/AIM:
Ixazomib, lenalidomide, and dexamethasone (IRd) have proven efficacy and an excellent safety profile in relapsed and/or refractory multiple myeloma (RRMM). However, there are limited reports on the real-world safety and effectiveness of IRd regimens in Asian patients with RRMM. PATIENTS ANDMETHODS:
This was a retrospective study of 60 patients with RRMM who were treated with IRd.RESULTS:
The median patient age was 68 years. Forty percent of patients did not meet the eligibility criteria for the TOURMALINE-MM1 trial. Patients received a median of one prior line of therapy. Non-hematologic adverse events (AEs) were more common than hematologic AEs. The most common AE was skin rash, followed by gastrointestinal toxicities. Most grade 3 or higher AEs were observed in less than 5% of the patients, except for skin rashes and infections. IRd therapy did not aggravate peripheral neuropathy (PN) in 20 of the 24 patients with pre-existing peripheral neuropathy. The overall response rate was 85%. After a median follow-up of 26.3 months, the median progression-free survival was 25.9 months and overall survival was not reached.CONCLUSION:
Ixazomib and Rd combination therapy had a comparable toxicity profile and effectiveness in real-world RRMM patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Periférico
/
Exantema
/
Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article