The traditional Chinese medicine Qiangjing tablet prevents blood-testis barrier injury induced by CdCl<sub>2</sub> through the PI3K/Akt/Rictor signaling pathway.

Shen, Yifeng; You, Yaodong; Zhu, Kun; Li, Guangsen; Huang, Xiaopeng; Chen, Diang; Yang, Fang; Dong, Liang; Li, Junjun; Yu, Xujun

The traditional Chinese medicine Qiangjing tablet prevents blood-testis barrier injury induced by CdCl₂ through the PI3K/Akt/Rictor signaling pathway.

Shen, Yifeng; You, Yaodong; Zhu, Kun; Li, Guangsen; Huang, Xiaopeng; Chen, Diang; Yang, Fang; Dong, Liang; Li, Junjun; Yu, Xujun.

Afiliação

Shen Y; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
You Y; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhu K; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li G; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Huang X; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen D; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yang F; Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Dong L; Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li J; Chengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yu X; Chengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Environ Toxicol ; 38(3): 591-603, 2023 Mar.

Article em En | MEDLINE | ID: mdl-36370150

Assuntos

Barreira Hematotesticular; Fosfatidilinositol 3-Quinases; Camundongos; Masculino; Animais; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Cádmio/metabolismo; Actinas/metabolismo; Tubulina (Proteína)/metabolismo; Tubulina (Proteína)/farmacologia; Ocludina/metabolismo; Medicina Tradicional Chinesa; Testículo; Transdução de Sinais; Fatores de Transcrição/metabolismo; Caderinas/metabolismo; Hormônio Foliculoestimulante/metabolismo; Claudinas/metabolismo; Espermatogênese

Palavras-chave

PI3K/Akt/Rictor signaling pathway; Qiangjing tablet; blood testis barrier; cadmium; male infertility

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematotesticular / Fosfatidilinositol 3-Quinases Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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