Synthesis of Gentamicin Minor Components: Gentamicin C1a and Gentamicin C2b.
Org Lett
; 24(46): 8564-8567, 2022 11 25.
Article
em En
| MEDLINE
| ID: mdl-36375034
ABSTRACT
Gentamicin C1a and the minor isomer C2b have been reported to have favorable properties in terms of antibacterial activity and toxicity compared to the commercial mixture from which they have previously been isolated by preparative high-performance liquid chromatography. We report straightforward syntheses of both compounds from readily available sisomicin by selective oxidation of the side chain in ring I, hydrogenation of the double bond in ring I to give the 5'-epi series, inversion of configuration at position 5' under thermodynamic conditions, and installation of the 6'-amino group by reductive amination.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gentamicinas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article