Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

White, Kate; Aldurdunji, Mohammed; Harris, John; Ortori, Catherine; Paine, Stuart

White, Kate; Aldurdunji, Mohammed; Harris, John; Ortori, Catherine; Paine, Stuart.

Afiliação

White K; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK.
Aldurdunji M; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK.
Harris J; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Ortori C; School of Biosciences, University of Nottingham, Sutton Bonington, UK.
Paine S; Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, UK.

Pharmacol Res Perspect ; 10(6): e01031, 2022 12.

Article em En | MEDLINE | ID: mdl-36380704

Assuntos

Anestésicos; Pregnanodionas; Humanos; Masculino; Feminino; Animais; Ratos; Ratos Endogâmicos Lew; Pregnanodionas/farmacologia; Anestésicos/farmacocinética; Meia-Vida

Palavras-chave

alfaxalone; anesthesia; neurosteroid; pharmacodynamics; population pharmacokinetics; rodent

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pregnanodionas / Anestésicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pregnanodionas / Anestésicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article