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Mercury, silver and selenium in serum before and after removal of amalgam restorations: results from a prospective cohort study in Norway.
Björkman, Lars; Musial, Frauke; Alræk, Terje; Werner, Erik L; Hamre, Harald J.
Afiliação
  • Björkman L; Dental Biomaterials Adverse Reaction Unit, NORCE Norwegian Research Centre AS, Bergen, Norway.
  • Musial F; Department of Clinical Dentistry, University of Bergen, Bergen, Norway.
  • Alræk T; Department of Community Medicine, Faculty of Health Sciences, The National Research Center in Complementary and Alternative Medicine (NAFKAM), UiT The Arctic University of Norway, Tromsø, Norway.
  • Werner EL; Department of Community Medicine, Faculty of Health Sciences, The National Research Center in Complementary and Alternative Medicine (NAFKAM), UiT The Arctic University of Norway, Tromsø, Norway.
  • Hamre HJ; Research Unit for General Practice, NORCE Norwegian Research Centre AS, Bergen, Norway.
Acta Odontol Scand ; 81(4): 298-310, 2023 May.
Article em En | MEDLINE | ID: mdl-36383213
OBJECTIVE: A prospective cohort study on changes of health complaints after removal of amalgam restorations was carried out at the request of the Norwegian Directorate of Health. The aim was to provide and evaluate experimental treatment to patients with health complaints attributed to dental amalgam fillings. METHODS: Patients (n = 32) with medically unexplained physical symptoms (MUPS), which were attributed to dental amalgam restorations had all their amalgam restorations removed and replaced with other dental restorative materials. Samples of blood were collected before and 1 year after removal of the fillings, and concentration of inorganic mercury (I-Hg), methylmercury (MeHg), silver (Ag) and selenium (Se) in serum was determined by inductively coupled plasma-sector field mass spectrometry. The comparison groups (one with MUPS but without attribution to amalgam [n = 28] and one group of healthy individuals [n = 19]) received no treatment. The participants responded to questionnaires at baseline and at follow-up after 1 and 5 years. RESULTS: Concentration of I-Hg and Ag in serum decreased significantly after removal of all amalgam restorations. Concentration of MeHg and Se in serum were not changed. Intensity of health complaints was significantly reduced after amalgam removal, but there were no statistically significant correlations between exposure indicators and health complaints. CONCLUSIONS: Removal of all amalgam restorations is followed by a decrease of concentration of I-Hg and Ag in serum. The results support the hypothesis that exposure to amalgam fillings causes an increase of the daily dose of both I-Hg and Ag. Even though intensity of health complaints decreased after removal of all amalgam restorations there was no clear evidence of a direct relationship between exposure and health complaints. Trial registration: The project is registered at Clinicaltrials.gov (NCT01682278).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Selênio / Mercúrio / Compostos de Metilmercúrio Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Selênio / Mercúrio / Compostos de Metilmercúrio Idioma: En Ano de publicação: 2023 Tipo de documento: Article