Effects of Salts and Surface Charge on the Biophysical Stability of a Low pI Monoclonal Antibody.

Rembert, Kelvin B; Zhang, Jifeng; Lee, Young Jong

Rembert, Kelvin B; Zhang, Jifeng; Lee, Young Jong.

Afiliação

Rembert KB; Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Zhang J; Department of Drug Delivery and Device Development, Medimmune-AstraZeneca, Gaithersburg, MD 20878, United States. Electronic address: zhangjif@yahoo.com.
Lee YJ; Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States. Electronic address: youngjong.lee@nist.gov.

J Pharm Sci ; 112(4): 947-953, 2023 04.

Article em En | MEDLINE | ID: mdl-36395898

Assuntos

Sais; Cloreto de Sódio; Sais/química; Anticorpos Monoclonais/química; Íons; Amidas; Concentração de Íons de Hidrogênio

Palavras-chave

Aggregation kinetics; Hofmeister series; Ion-protein interactions; Monoclonal antibody; Thermal stability; Unfolding kinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sais / Cloreto de Sódio Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sais / Cloreto de Sódio Idioma: En Ano de publicação: 2023 Tipo de documento: Article