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CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis.
Shi, Hongxue; Wang, Xiaobo; Li, Fang; Gerlach, Brennan D; Yurdagul, Arif; Moore, Mary P; Zeldin, Sharon; Zhang, Hanrui; Cai, Bishuang; Zheng, Ze; Valenti, Luca; Tabas, Ira.
Afiliação
  • Shi H; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Wang X; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Li F; Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Gerlach BD; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Yurdagul A; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Moore MP; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Zeldin S; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Zhang H; Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Cai B; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Zheng Z; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano and Fondazione Ca' Granda Ospedale Maggiore Policlinico Milano, Milano 20122, Italy.
  • Tabas I; Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sci Transl Med ; 14(672): eabp8309, 2022 11 23.
Article em En | MEDLINE | ID: mdl-36417485
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2022 Tipo de documento: Article