Association between uric acid levels and incidence of type 2 diabetes: Population-based Panasonic cohort study 11.
Diabetes Res Clin Pract
; 195: 110179, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36427625
ABSTRACT
AIMS:
This cohort study intended to assess the association between serum uric acid levels and incidence of type 2 diabetes in a Japanese population.METHODS:
Individuals who participated a medical health checkup program carried out by Panasonic Corporation from 2008 to 2018 were included in this study. A total of 122,123 participants (92,718 men and 29,405 women) were included. During the research period, 6,386 participants developed type 2 diabetes.RESULTS:
Multivariate analysis showed that, in men, serum uric acid levels were not significantly associated with incident type 2 diabetes after adjusting for diabetes risk factors. However, in women, the risk of type 2 diabetes incidence was higher in the group with uric acid levels 5.1-6.0 mg/dL (hazard ratio, 2.01 [95 % confidence interval 1.26-3.42]) or > 6.1 mg/dL (hazard ratio, 1.85 [95 % confidence interval 1.11-3.22]) than in the group with uric acid levels ≤ 3 mg/dL. Furthermore, in women, the area under the receiver operating characteristic curve and optimized cut-off values of uric acid for the incidence of type 2 diabetes at 10 years were 0.720 and 4.8 mg/dL, respectively.CONCLUSIONS:
Serum uric acid levels were associated with incident type 2 diabetes in Japanese women but not in Japanese men.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article