Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches.
Cells
; 11(22)2022 11 11.
Article
em En
| MEDLINE
| ID: mdl-36429001
ABSTRACT
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases. γδ T cells are excellent candidates for cellular immunotherapy due to their unique properties to recognize and destroy tumors or infected cells. They do not depend on the recognition of a single antigen but rather a broad-spectrum of diverse ligands through expression of various cytotoxic receptors. In this manuscript, we review major characteristics of the most abundant circulating γδ subpopulation, Vδ2 T cells, their immunotherapeutic potential, recent advances in expansion protocols, their preclinical and clinical applications for several infectious diseases and malignancies, and how additional modulation could enhance their therapeutic potential.
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MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T gama-delta
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article