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Hyaluronic acid-based hydrogels: Drug diffusion investigated by HR-MAS NMR and release kinetics.
Vanoli, Valeria; Delleani, Sara; Casalegno, Mosè; Pizzetti, Fabio; Makvandi, Pooyan; Haugen, Havard; Mele, Andrea; Rossi, Filippo; Castiglione, Franca.
Afiliação
  • Vanoli V; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy.
  • Delleani S; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy.
  • Casalegno M; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy. Electronic address: mose.casalegno@polimi.it.
  • Pizzetti F; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy.
  • Makvandi P; Istituto Italiano di Tecnologia, Centre for Materials Interfaces, viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.
  • Haugen H; Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, PO Box 1109, Blindern, NO-0317 Oslo, Norway.
  • Mele A; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy.
  • Rossi F; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy.
  • Castiglione F; Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy. Electronic address: franca.castiglione@polimi.it.
Carbohydr Polym ; 301(Pt A): 120309, 2023 Feb 01.
Article em En | MEDLINE | ID: mdl-36436870
ABSTRACT
Hydrogels based on hyaluronic acid (HA) and agarose-carbomer (AC) raised an increasing interest as drug delivery systems. The complex architecture of the polymer network, such as mesh size, HA molecular weight and drug-polymer non covalent interactions across the 3D polymer matrix strongly influence the release capability/profile of these materials. In this study, AC-HA hydrogels with different mesh sizes have been prepared and characterised. High Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy has been used to investigate the motion of two drugs, such as ethosuximide (neutral molecule) and sodium salicylate (net negative charge) within the AC and AC-HA hydrogel networks. Analysis of the experimental data provides evidence of superdiffusive motion for all formulations containing sodium salicylate, while ethosuximide molecules undergo unrestricted diffusion within the gel matrix. We further speculate that the superdiffusive motion, observed at the nanoscale, can be responsible for the faster release of sodium salicylate from all hydrogel formulations.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Ácido Hialurônico Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Ácido Hialurônico Idioma: En Ano de publicação: 2023 Tipo de documento: Article