Atherosclerosis and endothelial mechanotransduction: current knowledge and models for future research.
Am J Physiol Cell Physiol
; 324(2): C488-C504, 2023 02 01.
Article
em En
| MEDLINE
| ID: mdl-36440856
ABSTRACT
Endothelium health is essential to the regulation of physiological vascular functions. Because of the critical capability of endothelial cells (ECs) to sense and transduce chemical and mechanical signals in the local vascular environment, their dysfunction is associated with a vast variety of vascular diseases and injuries, especially atherosclerosis and subsequent cardiovascular diseases. This review describes the mechanotransduction events that are mediated through ECs, the EC subcellular components involved, and the pathways reported to be potentially involved. Up-to-date research efforts involving in vivo animal models and in vitro biomimetic models are also discussed, including their advantages and drawbacks, with recommendations on future modeling approaches to aid the development of novel therapies targeting atherosclerosis and related cardiovascular diseases.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Aterosclerose
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article