The potential link between Covid-19 and multiple myeloma: A new saga.
Immun Inflamm Dis
; 10(12): e701, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36444620
ABSTRACT
BACKGROUND:
Covid-19 is considered a primary respiratory disease-causing viral pneumonia and, in severe cases, leads to acute lung injury and acute respiratory distress syndrome (ARDS). In addition, though, extra-pulmonary manifestations of Covid-19 have been shown. Furthermore, severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2) infection may coexist with several malignancies, including multiple myeloma (MM).METHODS:
This critical literature review aimed to find the potential association between SARS-CoV-2 infection and MM in Covid-19 patients with underlying MM. Narrative literature and databases search revealed that ARDS is developed in both MM and Covid-19 due to hypercalcemia and proteasome dysfunction.RESULTS:
Notably, the expression of angiogenic factors and glutamine deficiency could link Covid-19 severity and MM in the pathogenesis of cardiovascular complications. MM and Covid-19 share thrombosis as a typical complication; unlike thrombosis in Covid-19, which reflects disease severity, thrombosis does not reflect disease severity in MM. In both conditions, thromboprophylaxis is essential to prevent pulmonary thrombosis and other thromboembolic disorders. Moreover, Covid-19 may exacerbate the development of acute kidney injury and neurological complications in MM patients.CONCLUSION:
These findings highlighted that MM patients might be a risk group for Covid-19 severity due to underlying immunosuppression and most of those patients need specific management in the Covid-19 era.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
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Tromboembolia Venosa
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COVID-19
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Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article