Disproportionately Low Albumin and High Neutrophil-to-Lymphocyte Ratio in Small Bowel Adenocarcinoma Patients With Long-Duration Crohn's Disease.
Clin Transl Gastroenterol
; 14(2): e00553, 2023 02 01.
Article
em En
| MEDLINE
| ID: mdl-36449698
ABSTRACT
INTRODUCTION:
Although Crohn's disease (CD) is a known risk factor of small bowel adenocarcinoma (SBA), early diagnosis remains a significant clinical challenge. Identification of biomarkers for SBA may lead to early detection.METHODS:
This is a retrospective study comparing albumin levels and neutrophil-to-lymphocyte ratio (NLR) of patients with long-standing CD who underwent small bowel resection with and without malignancy.RESULTS:
Forty-two patients with CD were included in this study (11 with SBA). Median NLR before surgery was 8.5 (interquartile range 6.2-31.3) in patients with SBA and 3.8 (interquartile range 2.8-5.3) for patients without SBA ( P < 0.05). Mean albumin levels before surgery were significantly lower among patients with SBA compared with patients without SBA (2.6 ± 0.6 g/dL vs 3.5 ± 0.6 g/dL, respectively, P < 0.05), despite patients with SBA being under longer total parenteral nutrition treatment duration.DISCUSSION:
CD patients with SBA diagnosis have increased NLR and lower albumin before surgery compared with CD patients without detection of SBA.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
/
Doença de Crohn
/
Neoplasias Duodenais
/
Neoplasias do Íleo
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article