4'-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics.
Chem Soc Rev
; 52(1): 248-276, 2023 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-36472161
ABSTRACT
The history and development of 4'-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4'-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4'-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article