Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides.
J Org Chem
; 87(24): 16860-16866, 2022 12 16.
Article
em En
| MEDLINE
| ID: mdl-36472915
ABSTRACT
In this paper we report the annulation reaction between 2-iodobenzaldehyde derivatives and various ynamides. This palladium-catalyzed reaction leads to rare polysubstituted amino-indenones in good yields with a regioselectivity up to complete. Remarkably, a regiodivergent selectivity has been identified between aryl and alkyl or silyl ynamides, with the first leading mainly to 2-amido-indenones and the second to 3-amido-indenones.
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Base de dados:
MEDLINE
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Paládio
Idioma:
En
Ano de publicação:
2022
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Article