Identification and Prioritization of PET Neuroimaging Targets for Microglial Phenotypes Associated with Microglial Activity in Alzheimer's Disease.

Bartolo, Nicole D; Mortimer, Niall; Manter, Mariah A; Sanchez, Nicholas; Riley, Misha; O'Malley, Tiernan T; Hooker, Jacob M

Bartolo, Nicole D; Mortimer, Niall; Manter, Mariah A; Sanchez, Nicholas; Riley, Misha; O'Malley, Tiernan T; Hooker, Jacob M.

Afiliação

Bartolo ND; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, United States.
Mortimer N; Human Biology and Data Science, Eisai Center for Genetics Guided Dementia Discovery, 35 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States.
Manter MA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, United States.
Sanchez N; Human Biology and Data Science, Eisai Center for Genetics Guided Dementia Discovery, 35 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States.
Riley M; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, United States.
O'Malley TT; Human Biology and Data Science, Eisai Center for Genetics Guided Dementia Discovery, 35 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States.
Hooker JM; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, United States.

ACS Chem Neurosci ; 13(24): 3641-3660, 2022 12 21.

Article em En | MEDLINE | ID: mdl-36473177

Assuntos

Doença de Alzheimer; Doenças Neurodegenerativas; Humanos; Doença de Alzheimer/diagnóstico por imagem; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Microglia/metabolismo; Proteômica; Doenças Neurodegenerativas/metabolismo; Neuroimagem; Tomografia por Emissão de Pósitrons/métodos

Palavras-chave

Alzheimer's disease; microglia; neuroimaging; positron emission tomography; single-cell RNA sequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Idioma: En Ano de publicação: 2022 Tipo de documento: Article