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Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells.
Purshouse, Karin; Friman, Elias T; Boyle, Shelagh; Dewari, Pooran Singh; Grant, Vivien; Hamdan, Alhafidz; Morrison, Gillian M; Brennan, Paul M; Beentjes, Sjoerd V; Pollard, Steven M; Bickmore, Wendy A.
Afiliação
  • Purshouse K; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom.
  • Friman ET; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Boyle S; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom.
  • Dewari PS; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom.
  • Grant V; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Hamdan A; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Morrison GM; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Brennan PM; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Beentjes SV; Centre for Regenerative Medicine and Cancer Research UK Edinburgh Centre, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, United Kingdom.
  • Pollard SM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
  • Bickmore WA; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom.
Elife ; 112022 12 07.
Article em En | MEDLINE | ID: mdl-36476408
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Células-Tronco Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Células-Tronco Idioma: En Ano de publicação: 2022 Tipo de documento: Article