Structural variants drive context-dependent oncogene activation in cancer.

Xu, Zhichao; Lee, Dong-Sung; Chandran, Sahaana; Le, Victoria T; Bump, Rosalind; Yasis, Jean; Dallarda, Sofia; Marcotte, Samantha; Clock, Benjamin; Haghani, Nicholas; Cho, Chae Yun; Akdemir, Kadir C; Tyndale, Selene; Futreal, P Andrew; McVicker, Graham; Wahl, Geoffrey M; Dixon, Jesse R

Xu, Zhichao; Lee, Dong-Sung; Chandran, Sahaana; Le, Victoria T; Bump, Rosalind; Yasis, Jean; Dallarda, Sofia; Marcotte, Samantha; Clock, Benjamin; Haghani, Nicholas; Cho, Chae Yun; Akdemir, Kadir C; Tyndale, Selene; Futreal, P Andrew; McVicker, Graham; Wahl, Geoffrey M; Dixon, Jesse R.

Afiliação

Xu Z; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Lee DS; Department of Life Sciences, University of Seoul, Seoul, South Korea.
Chandran S; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Le VT; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Bump R; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Yasis J; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Dallarda S; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Marcotte S; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Clock B; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Haghani N; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Cho CY; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Akdemir KC; Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, TX, USA.
Tyndale S; Department of Neurosurgery, UT MD Anderson Cancer Center, TX, Houston, USA.
Futreal PA; Integrative Biology Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
McVicker G; Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, TX, USA.
Wahl GM; Integrative Biology Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.
Dixon JR; Gene Expression Laboratory; Salk Institute for Biological Studies, La Jolla, CA, USA.

Nature ; 612(7940): 564-572, 2022 12.

Article em En | MEDLINE | ID: mdl-36477537

Assuntos

Variação Estrutural do Genoma; Neoplasias; Proteínas Oncogênicas; Oncogenes; Humanos; Cromatina/genética; Rearranjo Gênico/genética; Variação Estrutural do Genoma/genética; Neoplasias/genética; Neoplasias/patologia; Oncogenes/genética; Proteínas Oncogênicas/química; Proteínas Oncogênicas/genética; Proteínas Oncogênicas/metabolismo; Cromossomos Humanos/genética; Linhagem Celular Tumoral; Elementos Facilitadores Genéticos/genética; Modelos Genéticos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Proteínas Oncogênicas / Variação Estrutural do Genoma / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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