Neural precursor cells tune striatal connectivity through the release of IGFBPL1.
Nat Commun
; 13(1): 7579, 2022 12 08.
Article
em En
| MEDLINE
| ID: mdl-36482070
ABSTRACT
The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion of insulin-like growth factor binding protein-like 1 (IGFBPL1). In mice, selective ablation of SVZ-eNPCs or selective abrogation of IGFBPL1 determined an impairment of striatal medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, and striatum-related behavioural dysfunctions. We also found IGFBPL1 expression in the human SVZ, foetal and induced-pluripotent stem cell-derived NPCs. Finally, we found a significant correlation between SVZ damage, reduction of striatum volume, and impairment of information processing speed in neurological patients. Our results highlight the physiological role of adult SVZ-eNPCs in supporting cognitive functions by regulating striatal neuronal activity.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina
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Ventrículos Laterais
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Proteínas Supressoras de Tumor
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Células-Tronco Neurais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article