Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma.

Zajec, Ziva; Dernovsek, Jaka; Distel, Martin; Gobec, Martina; Tomasic, Tihomir

Zajec, Ziva; Dernovsek, Jaka; Distel, Martin; Gobec, Martina; Tomasic, Tihomir.

Afiliação

Zajec Z; University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia.
Dernovsek J; University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia.
Distel M; St. Anna Children's Cancer Research Institute, Zimmermannplatz 10, 1090 Vienna, Austria.
Gobec M; University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia.
Tomasic T; University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia. Electronic address: tihomir.tomasic@ffa.uni-lj.si.

Bioorg Chem ; 131: 106311, 2023 02.

Article em En | MEDLINE | ID: mdl-36495678

Assuntos

Antineoplásicos; Neoplasias Ósseas; Sarcoma de Ewing; Humanos; Criança; Sarcoma de Ewing/tratamento farmacológico; Sarcoma de Ewing/genética; Sarcoma de Ewing/patologia; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias Ósseas/tratamento farmacológico; Neoplasias Ósseas/patologia; Linhagem Celular Tumoral

Palavras-chave

Cancer; Ewing sarcoma; Hsp90; Inhibitor; Molecular modelling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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