Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease.

Liu, Pengfei; Anandhan, Annadurai; Chen, Jinjing; Shakya, Aryatara; Dodson, Matthew; Ooi, Aikseng; Chapman, Eli; White, Eileen; Garcia, Joe Gn; Zhang, Donna D

Liu, Pengfei; Anandhan, Annadurai; Chen, Jinjing; Shakya, Aryatara; Dodson, Matthew; Ooi, Aikseng; Chapman, Eli; White, Eileen; Garcia, Joe Gn; Zhang, Donna D.

Afiliação

Liu P; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA; National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; International Joint Researc
Anandhan A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Chen J; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Shakya A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Dodson M; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Ooi A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
Chapman E; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.
White E; Department of Molecular Biology and Biochemistry, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Garcia JG; Department of Medicine and Arizona Health Sciences Center, University of Arizona, Tucson, AZ, 85721, USA.
Zhang DD; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA; The University of Arizona Cancer Center, University of Arizona, Tucson, AZ, 85721, USA. Electronic address: dzhang@pharmacy.arizona.edu.

Redox Biol ; 59: 102570, 2023 02.

Article em En | MEDLINE | ID: mdl-36495698

Assuntos

Hepatopatia Gordurosa não Alcoólica; Animais; Camundongos; Humanos; Hepatopatia Gordurosa não Alcoólica/genética; Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Autofagossomos/metabolismo; Ácidos Graxos/metabolismo; Obesidade/metabolismo; Morte Celular; Dieta Hiperlipídica/efeitos adversos; Camundongos Endogâmicos C57BL; Fígado/metabolismo; Metabolismo dos Lipídeos

Palavras-chave

AKT; AMPK; ATG7; Autophagy; Fatty acids; Ferroptosis; High fat diet; KEAP1; Liver steatosis; NAFLD; NRF2; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2023 Tipo de documento: Article