Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway.

Gao, Xiangjie; Lei, Guanxiong; Wang, Bin; Deng, Zhong; Karges, Johannes; Xiao, Haihua; Tan, Donghui

Gao, Xiangjie; Lei, Guanxiong; Wang, Bin; Deng, Zhong; Karges, Johannes; Xiao, Haihua; Tan, Donghui.

Afiliação

Gao X; Affiliated Hospital of Xiangnan University, Chenzhou, Hunan Province, 423000, China.
Lei G; Xiangnan University, Chenzhou, Hunan Province, 423000, China.
Wang B; Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, Hunan Province, 423000, China.
Deng Z; Hunan Engineering Research Center of Advanced Embedded Computing and Intelligent Medical Systems, Xiangnan University, Chenzhou, Hunan Province, 423000, China.
Karges J; Affiliated Hospital of Xiangnan University, Chenzhou, Hunan Province, 423000, China.
Xiao H; Xiangnan University, Chenzhou, Hunan Province, 423000, China.
Tan D; Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, Hunan Province, 423000, China.

Adv Sci (Weinh) ; 10(4): e2205241, 2023 02.

Article em En | MEDLINE | ID: mdl-36504435

Assuntos

Nanopartículas; Pró-Fármacos; Camundongos; Animais; Inibidores de Checkpoint Imunológico; Platina; Imunoterapia/métodos; Nanopartículas/química; Polímeros

Palavras-chave

immunotherapy; nanoparticle; oxaliplatin; polymer with a cyclic seven-membered ring (PC7A); stimulator of interferon genes (STING)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Ano de publicação: 2023 Tipo de documento: Article