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Diabetic Retinopathy and Dementia Association, Beyond Diabetes Severity.
Lee, Cecilia S; Krakauer, Chloe; Su, Yu-Ru; Walker, Rod L; Blazes, Marian; McCurry, Susan M; Bowen, James D; McCormick, Wayne C; Lee, Aaron Y; Boyko, Edward J; O'Hare, Ann M; Larson, Eric B; Crane, Paul K.
Afiliação
  • Lee CS; Department of Ophthalmology, University of Washington, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.); Roger and Angie Karalis Johnson Retina Center, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.). Electronic address: leecs2@uw.edu.
  • Krakauer C; Department of Biostatistics, University of Washington, Seattle, Washington, USA (C.K.); Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA (C.K., Y-R.S., R.L.W., E.B.L.).
  • Su YR; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA (C.K., Y-R.S., R.L.W., E.B.L.).
  • Walker RL; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA (C.K., Y-R.S., R.L.W., E.B.L.).
  • Blazes M; Department of Ophthalmology, University of Washington, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.); Roger and Angie Karalis Johnson Retina Center, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.).
  • McCurry SM; School of Nursing, University of Washington, Seattle, Washington, USA (S.M.M.).
  • Bowen JD; Department of Neurology, Swedish Medical Center, Seattle, Washington, USA (J.D.B.).
  • McCormick WC; Department of Medicine, University of Washington, Seattle, Washington, USA (W.C.M., E.J.B, E.B.L., P.K.C.).
  • Lee AY; Department of Ophthalmology, University of Washington, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.); Roger and Angie Karalis Johnson Retina Center, Seattle, Washington, USA (C.S.L., M.B., A.Y.L.).
  • Boyko EJ; Department of Medicine, University of Washington, Seattle, Washington, USA (W.C.M., E.J.B, E.B.L., P.K.C.); Veterans Affairs Puget Sound Healthcare System, Seattle, Washington, USA (E.J.B., A.M.O).
  • O'Hare AM; Veterans Affairs Puget Sound Healthcare System, Seattle, Washington, USA (E.J.B., A.M.O).
  • Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA (C.K., Y-R.S., R.L.W., E.B.L.); Department of Medicine, University of Washington, Seattle, Washington, USA (W.C.M., E.J.B, E.B.L., P.K.C.).
  • Crane PK; Department of Medicine, University of Washington, Seattle, Washington, USA (W.C.M., E.J.B, E.B.L., P.K.C.).
Am J Ophthalmol ; 249: 90-98, 2023 05.
Article em En | MEDLINE | ID: mdl-36513155
PURPOSE: To investigate whether associations between diabetic retinopathy (DR) and dementia and Alzheimer's disease (AD) remain significant after controlling for several measures of diabetes severity. DESIGN: Retrospective cohort study. METHODS: Adult Changes in Thought (ACT) is a prospective cohort study of adults aged ≥65 years, randomly selected and recruited from the membership rolls of Kaiser Permanente Washington, who are dementia free at enrollment and followed biennially until incident dementia. The ACT participants were included in this study if they had type 2 diabetes mellitus at enrollment or developed it during follow-up, and data were collected through September, 2018 (3516 person-years of follow-up). Diabetes was defined by ≥ 2 diabetes medication fills in 1 year. Diagnosis of DR was based on International Classification of Diseases Ninth and Tenth Revision codes. Estimates of microalbuminuria, long-term glycemia, and renal function from longitudinal laboratory records were used as indicators of diabetes severity. Alzheimer's disease and dementia were diagnosed using research criteria at expert consensus meetings. RESULTS: A total of 536 participants (median baseline age 75 [interquartile range 71-80], 54% women) met inclusion criteria. Significant associations between DR >5 years duration with dementia (hazard ratio 1.81 [95% CI 1.23, 2.65]) and AD (1.80 [1.15, 2.82]) were not altered by adjustment for estimates of microalbuminuria, long-term glycemia, and renal function (dementia: 1.69 [1.14, 2.50]; AD: 1.73 [1.10, 2.74]). CONCLUSIONS: Among people with type 2 diabetes, DR itself appears to be an important biomarker of dementia risk in addition to glycemia and renal complications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Retinopatia Diabética / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Retinopatia Diabética / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article