Precise engineering of disulfide bond-bridged prodrug nanoassemblies to balance antitumor efficacy and safety.

Sun, Yixin; Wang, Simeng; Li, Yaqi; Wang, Danping; Zhang, Yu; Zhang, Haotian; Lei, Hongrui; Liu, Xiaohong; Sun, Jin; Sun, Bingjun; He, Zhonggui

Sun, Yixin; Wang, Simeng; Li, Yaqi; Wang, Danping; Zhang, Yu; Zhang, Haotian; Lei, Hongrui; Liu, Xiaohong; Sun, Jin; Sun, Bingjun; He, Zhonggui.

Afiliação

Sun Y; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang S; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li Y; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang D; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang Y; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang H; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lei H; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu X; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Sun J; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunjin@syphu.edu.cn.
Sun B; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: sunbingjun_spy@sina.com.
He Z; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: hezhgui_student@aliyun.com.

Acta Biomater ; 157: 417-427, 2023 02.

Article em En | MEDLINE | ID: mdl-36513247

Assuntos

Nanopartículas; Pró-Fármacos; Pró-Fármacos/química; Linhagem Celular Tumoral; Paclitaxel/química; Liberação Controlada de Fármacos; Dissulfetos/química; Carbono; Sistemas de Liberação de Medicamentos; Nanopartículas/química

Palavras-chave

Antitumor therapy; Disulfide bond; Efficacy; Prodrug-based nanoassemblies; Safety

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Ano de publicação: 2023 Tipo de documento: Article