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Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity.
Huang, Jinbo; Zhang, Jun; Xu, Wenchao; Wu, Qiong; Zeng, Rongsheng; Liu, Zhichao; Tao, Wenhui; Chen, Qian; Wang, Yongqing; Zhu, Wei-Guo.
Afiliação
  • Huang J; Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, and International Cancer Center, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Zhang J; Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Xu W; Health Science Centre School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, China.
  • Wu Q; Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, and International Cancer Center, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Zeng R; Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Liu Z; Health Science Centre School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, China.
  • Tao W; Marshall Laboratory of Biomedical Engineering, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Chen Q; Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, and International Cancer Center, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Wang Y; Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, China.
  • Zhu WG; Health Science Centre School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, China.
J Med Chem ; 66(2): 1186-1209, 2023 01 26.
Article em En | MEDLINE | ID: mdl-36516047
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Histona Desacetilases Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Histona Desacetilases Idioma: En Ano de publicação: 2023 Tipo de documento: Article