Baseline immune signature score of Tregs × HLA-DR+CD4+ T cells × PD1+CD8+ T cells predicts outcome to immunotherapy in cancer patients.

Mispelbaum, Rebekka; Hattenhauer, Sandra Tessa; Held, Stefanie Andrea Erika; Brossart, Peter; Heine, Annkristin

Baseline immune signature score of Tregs × HLA-DR⁺CD4⁺ T cells × PD1⁺CD8⁺ T cells predicts outcome to immunotherapy in cancer patients.

Mispelbaum, Rebekka; Hattenhauer, Sandra Tessa; Held, Stefanie Andrea Erika; Brossart, Peter; Heine, Annkristin.

Afiliação

Mispelbaum R; Department of Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Hattenhauer ST; Department of Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Held SAE; Department of Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Brossart P; Department of Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany.
Heine A; Department of Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany.

Front Immunol ; 13: 1054161, 2022.

Article em En | MEDLINE | ID: mdl-36518753

Assuntos

Antígeno B7-H1; Neoplasias; Humanos; Antígeno B7-H1/metabolismo; Linfócitos T CD4-Positivos; Linfócitos T CD8-Positivos; Antígenos HLA-DR; Imunoterapia/métodos; Neoplasias/terapia; Estudos Retrospectivos

Palavras-chave

cancer; immune signature; immunotherapy; peripheral immune cells; prediction; response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article