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Weight and Metabolic Changes After Switching From Tenofovir Alafenamide/Emtricitabine (FTC)+Dolutegravir (DTG), Tenofovir Disoproxil Fumarate (TDF)/FTC + DTG, and TDF/FTC/Efavirenz to TDF/Lamivudine/DTG.
Bosch, Bronwyn; Akpomiemie, Godspower; Chandiwana, Nomathemba; Sokhela, Simiso; Hill, Andrew; McCann, Kaitlyn; Qavi, Ambar; Mirchandani, Manya; Venter, Willem Daniel Francois.
Afiliação
  • Bosch B; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Akpomiemie G; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Chandiwana N; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Sokhela S; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Hill A; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
  • McCann K; Faculty of Medicine, Imperial College, London, United Kingdom.
  • Qavi A; Faculty of Medicine, Imperial College, London, United Kingdom.
  • Mirchandani M; Faculty of Medicine, Imperial College, London, United Kingdom.
  • Venter WDF; Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Clin Infect Dis ; 76(8): 1492-1495, 2023 04 17.
Article em En | MEDLINE | ID: mdl-36519389
ABSTRACT
Participants randomized to first-line tenofovir alafenamide (TAF)/emtricitabine (FTC)+dolutegravir (DTG), tenofovir disoproxil fumarate (TDF)/FTC + DTG, or TDF/FTC/efavirenz (EFV) for 192 weeks were then switched to TDF/lamivudine (3TC)/DTG for 52 weeks. Participants switching either TAF/FTC + DTG or TDF/FTC/EFV to TDF/3TC/DTG showed statistically significant reductions in weight, low-density lipoprotein, triglycerides, glucose and glycated hemoglobin.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV Idioma: En Ano de publicação: 2023 Tipo de documento: Article