Your browser doesn't support javascript.
loading
Soft strain-insensitive bioelectronics featuring brittle materials.
Zhao, Yichao; Wang, Bo; Tan, Jiawei; Yin, Hexing; Huang, Ruyi; Zhu, Jialun; Lin, Shuyu; Zhou, Yan; Jelinek, David; Sun, Zhengyang; Youssef, Kareem; Voisin, Laurent; Horrillo, Abraham; Zhang, Kaiji; Wu, Benjamin M; Coller, Hilary A; Lu, Daniel C; Pei, Qibing; Emaminejad, Sam.
Afiliação
  • Zhao Y; Interconnected and Integrated Bioelectronics Lab (I²BL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Wang B; Department of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Tan J; Interconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Yin H; Interconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Huang R; Department of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Zhu J; Department of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Lin S; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Zhou Y; Neuromotor Recovery and Rehabilitation Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Jelinek D; Brain Research Institute, University of California, Los Angeles, CA, USA.
  • Sun Z; Interconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Youssef K; Interconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Voisin L; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Horrillo A; Neuromotor Recovery and Rehabilitation Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Zhang K; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
  • Wu BM; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Coller HA; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
  • Lu DC; Department of Materials Science and Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA.
  • Pei Q; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
  • Emaminejad S; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
Science ; 378(6625): 1222-1227, 2022 12 16.
Article em En | MEDLINE | ID: mdl-36520906
Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes with established electrochemical functionalities are rigid and mechanically mismatched with tissue. Whereas conductive materials with tissue-like softness and stretchability are demonstrated, when applied to electrochemically probe tissue, their performance is distorted by strain and corrosion. We devise a layered architectural composite design that couples strain-induced cracked films with a strain-isolated out-of-plane conductive pathway and in-plane nanowire networks to eliminate strain effects on device electrochemical performance. Accordingly, we developed a library of stretchable, highly conductive, and strain-insensitive bioelectrodes featuring clinically established brittle interfacial materials (iridium-oxide, gold, platinum, and carbon). We paired these bioelectrodes with different electrochemical probing methods (amperometry, voltammetry, and potentiometry) and demonstrated strain-insensitive sensing of multiple biomarkers and in vivo neuromodulation.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Elastômeros / Neuroestimuladores Implantáveis Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Elastômeros / Neuroestimuladores Implantáveis Idioma: En Ano de publicação: 2022 Tipo de documento: Article