Incorporating a Lipophilic Disulfide-Bridged Linoleic Prodrug into a Self-Microemulsifying Drug Delivery System to Facilitate Oral Absorption of Paclitaxel.

Zhang, Mingyang; Guo, Chunlin; Miao, Yifan; He, Zhonggui; Tian, Chutong; Sun, Jin

Zhang, Mingyang; Guo, Chunlin; Miao, Yifan; He, Zhonggui; Tian, Chutong; Sun, Jin.

Afiliação

Zhang M; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.
Guo C; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.
Miao Y; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.
He Z; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.
Tian C; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.
Sun J; Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, PR China.

Mol Pharm ; 20(1): 461-472, 2023 01 02.

Article em En | MEDLINE | ID: mdl-36525349

Assuntos

Pró-Fármacos; Paclitaxel; Dissulfetos; Distribuição Tecidual; Emulsões; Sistemas de Liberação de Medicamentos; Solubilidade; Disponibilidade Biológica; Administração Oral

Palavras-chave

lipidic prodrug; oral chemotherapy; paclitaxel; self-microemulsifying drug delivery system

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos Idioma: En Ano de publicação: 2023 Tipo de documento: Article