Pummerer-like Rearrangement Induced Cascade Reactions: Synthesis of Highly Functionalized Imidazoles.
J Org Chem
; 88(1): 739-744, 2023 01 06.
Article
em En
| MEDLINE
| ID: mdl-36525640
ABSTRACT
Imidazoles are among the most important pharmacophores in medicinal chemistry. Herein we report a tandem protocol for the synthesis of highly substituted imidazoles through Pummerer-like rearrangement induced cascade reactions including two carbon-nitrogen bond formations, and concomitant aromatization under mild reaction conditions. This procedure gives imidazole derivatives bearing numerous functional groups and could be used for modifying natural products as well as pharmaceuticals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imidazóis
/
Nitroimidazóis
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article