Recurrent Lisch Epithelial Corneal Dystrophy Treated With 5-Fluorouracil: A Case Report and Review of the Literature.
Cornea
; 42(5): 645-647, 2023 May 01.
Article
em En
| MEDLINE
| ID: mdl-36533990
ABSTRACT
PURPOSE:
The aim of the study was to describe a case of Lisch epithelial corneal dystrophy (LECD), review its clinical and histopathological features and diagnostic imaging, and introduce a novel treatment approach using topical 5-fluorouracil (5-FU).METHODS:
A 65-year-old woman presented with a recurrent left-sided corneal lesion consistent with LECD. The lesion was evaluated clinically, with high-resolution optical coherence tomography (HR-OCT), and histologically. The lesion was successfully treated with two 1-week cycles of topical 5-FU.RESULTS:
Slit-lamp examination showed an opalescent, whorl-shaped corneal lesion. HR-OCT revealed a trapezoidal area of normal thickness epithelial hyperreflectivity. Histopathology demonstrated a mucosal epithelium with foamy cytoplasm and increased cell size consistent with LECD. Treatment with topical 5-FU resulted in marked clearance of the corneal lesion on slit-lamp examination and HR-OCT.CONCLUSIONS:
5-FU may be considered as a treatment option for LECD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Distrofias Hereditárias da Córnea
/
Fluoruracila
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article