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Quantitative relationships of perfluoroalkyl acids in drinking water associated with serum concentrations above background in adults living near contamination hotspots in Sweden.
Johanson, Gunnar; Gyllenhammar, Irina; Ekstrand, Carl; Pyko, Andrei; Xu, Yiyi; Li, Ying; Norström, Karin; Lilja, Karl; Lindh, Christian; Benskin, Jonathan P; Georgelis, Antonios; Forsell, Karl; Jakobsson, Kristina; Glynn, Anders; Vogs, Carolina.
Afiliação
  • Johanson G; Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07, Uppsala, Sweden; Unit of Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, SE
  • Gyllenhammar I; Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07, Uppsala, Sweden; Swedish Food Agency, Box 622, 751 26, Uppsala, Sweden.
  • Ekstrand C; Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07, Uppsala, Sweden.
  • Pyko A; Center for Occupational and Environmental Health, Region Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Xu Y; School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, P.O Box 414, 405 30, Gothenburg, Sweden.
  • Li Y; School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, P.O Box 414, 405 30, Gothenburg, Sweden.
  • Norström K; Swedish Environmental Protection Agency, Circular Economy Department, 106 48, Stockholm, Sweden.
  • Lilja K; Swedish Environmental Protection Agency, Circular Economy Department, 106 48, Stockholm, Sweden.
  • Lindh C; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
  • Benskin JP; Department of Environmental Science, Stockholm University, Sweden.
  • Georgelis A; Center for Occupational and Environmental Health, Region Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Forsell K; Occupational and Environmental Medicine, Norrland University Hospital, Umeå, Sweden.
  • Jakobsson K; School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, P.O Box 414, 405 30, Gothenburg, Sweden; Occupational and Environmental Medicine, Sahlgrenska University Hospital, Box 414, 405 30, Gothenburg, Sweden.
  • Glynn A; Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07, Uppsala, Sweden.
  • Vogs C; Division of Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), Box 7028, 750 07, Uppsala, Sweden. Electronic address: Carolina.vogs@slu.se.
Environ Res ; 219: 115024, 2023 02 15.
Article em En | MEDLINE | ID: mdl-36535390
ABSTRACT
Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quantitative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PFPeA, PFHxA, PFHpA, and PFBS) and long-chained PFAAs (PFOA, PFNA, PFDA, PFHxS and PFOS) were measured in DW and serum. We matched DW and serum concentrations for a total of 398 subjects living or working in areas receiving contaminated DW and in one non-contaminated area. Thereafter, linear regression analysis with and without adjustments for co-variates was conducted. This enabled to derive (i) serum concentrations at background exposure (CB) from sources other than local DW exposure (i.e. food, dust and textiles) at 0 ng/L DW concentration, (ii) population-mean PFAA serumwater ratios (SWR) and (iii) PFAA concentrations in DW causing observable elevated serum PFAA concentrations above background variability. Median concentrations of the sum of nine PFAAs ranged between 2.8 and 1790 ng/L in DW and between 7.6 and 96.9 ng/mL in serum. DW concentration was the strongest predictor, resulting in similar unadjusted and adjusted regression coefficients. Mean CB ranged from <0.1 (PFPeA, PFHpA, PFBS) to 5.1 ng/mL (PFOS). Serum concentrations increased significantly with increasing DW concentrations for all PFAAs except for PFPeA with SWRs ranging from <10 (PFHxA, PFHpA and PFBS) to 111 (PFHxS). Observed elevated serum concentrations above background variability were reached at DW concentrations between 24 (PFOA) and 357 ng/L (PFHxA). The unadjusted linear regression predictions agreed well with serum concentrations previously reported in various populations exposed to low and high DW levels of PFOA, PFHxS and PFOS. The quantitative relationships derived herein should be helpful to translate PFAA concentrations in DW to concentrations in serum at the population level.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Água Potável / Ácidos Alcanossulfônicos / Fluorocarbonos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluentes Químicos da Água / Água Potável / Ácidos Alcanossulfônicos / Fluorocarbonos Idioma: En Ano de publicação: 2023 Tipo de documento: Article