A practical approach for PD-L1 evaluation in gastroesophageal cancer.
Pathologica
; 115(2): 57-70, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-36537078
PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability.This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC).
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MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Neoplasias Esofágicas
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Adenocarcinoma
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Carcinoma de Células Escamosas do Esôfago
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article