Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.

Smith, Emily J; Beaumont, Ross E; McClellan, Alyce; Sze, Cheryl; Palomino Lago, Esther; Hazelgrove, Liberty; Dudhia, Jayesh; Smith, Roger K W; Guest, Deborah J

Smith, Emily J; Beaumont, Ross E; McClellan, Alyce; Sze, Cheryl; Palomino Lago, Esther; Hazelgrove, Liberty; Dudhia, Jayesh; Smith, Roger K W; Guest, Deborah J.

Afiliação

Smith EJ; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK. ejsmith@rvc.ac.uk.
Beaumont RE; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
McClellan A; Centre for Preventative Medicine, Animal Health Trust, Newmarket, Suffolk, CB8 7UU, UK.
Sze C; Centre for Preventative Medicine, Animal Health Trust, Newmarket, Suffolk, CB8 7UU, UK.
Palomino Lago E; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
Hazelgrove L; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
Dudhia J; Kingston University, River House, 53-57 High Street, Kingston upon Thames, Surrey, KT1 1LQ, UK.
Smith RKW; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.
Guest DJ; Department of Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.

Cell Tissue Res ; 391(3): 523-544, 2023 Mar.

Article em En | MEDLINE | ID: mdl-36543895

Assuntos

Células-Tronco Mesenquimais; Tendinopatia; Humanos; Animais; Cavalos; Fator de Necrose Tumoral alfa/metabolismo; Interleucina-1beta/metabolismo; NF-kappa B/metabolismo; Proteína Antagonista do Receptor de Interleucina 1/genética; Proteína Antagonista do Receptor de Interleucina 1/metabolismo; Interferon gama/metabolismo; Tenócitos/metabolismo; Tendinopatia/metabolismo; Células Cultivadas

Palavras-chave

Cytokine; Horse; Inflammation; Mesenchymal stem/stromal cell; Tendon

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tendinopatia / Células-Tronco Mesenquimais Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tendinopatia / Células-Tronco Mesenquimais Idioma: En Ano de publicação: 2023 Tipo de documento: Article