Doxorubicin-isoniazid conjugate regulates immune response and tumor microenvironment to enhance cancer therapy.

Jin, Chan; Li, Jinbo; Yang, Xiaoguang; Zhou, Shuang; Li, Chang; Yu, Jiang; Wang, Zhaomeng; Wang, Dun; He, Zhonggui; Jiang, Yiguo; Wang, Yongjun

Jin, Chan; Li, Jinbo; Yang, Xiaoguang; Zhou, Shuang; Li, Chang; Yu, Jiang; Wang, Zhaomeng; Wang, Dun; He, Zhonggui; Jiang, Yiguo; Wang, Yongjun.

Afiliação

Jin C; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Li J; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Yang X; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhou S; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Li C; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Yu J; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Wang Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Wang D; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China.
Jiang Y; Suzhou Science & Technology Town Hospital, Gusu School, Nanjing Medical University, Suzhou 215153, China. Electronic address: jiangyiguo@njmu.edu.cn.
Wang Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road, Shenyang 110016, China. Electronic address: wangyongjun@syphu.edu.cn.

Int J Pharm ; 631: 122509, 2023 Jan 25.

Article em En | MEDLINE | ID: mdl-36549403

Assuntos

Neoplasias da Mama; Isoniazida; Humanos; Feminino; Isoniazida/química; Microambiente Tumoral; Linfócitos T CD8-Positivos; Doxorrubicina; Neoplasias da Mama/tratamento farmacológico; Imunoterapia; Imunidade; Linhagem Celular Tumoral

Palavras-chave

Doxorubicin; Epithelial mesenchymal transformation; Immunotherapy; Isoniazid; Monoamine oxidase A; pH sensitive

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Isoniazida Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Isoniazida Idioma: En Ano de publicação: 2023 Tipo de documento: Article