Tricholosterols A-D, four new ergosterol derivatives from the mushroom Tricholoma terreum.
Steroids
; 191: 109157, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36549636
ABSTRACT
Four ergosterol derivatives, named tricholosterols A-D (1-4), have been isolated from the fruiting bodies of Tricholoma terreum. Their chemical structures have been determined using a combination of spectroscopic analysis as well as computational methods. Compound 1 possesses a rare D-ring opening ergosterol skeleton, while compounds 2-4 are rare degraded ergosterols. Compounds 1 and 4 exhibited moderate inhibitory activity against NO production with IC50 values of 27.6 and 31.8 µM, respectively. This is the first report of steroids from T. terreum.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ergosterol
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Tricholoma
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Óxido Nítrico
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article