Evaluation of red blood cell transfusion threshold in the management of brain-dead organ donors.
Medicine (Baltimore)
; 101(50): e32353, 2022 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-36550826
ABSTRACT
The disparity between the demand and supply of organs has necessitated an expansion of the criteria for organ donation. Consequently, numerous guidelines have been proposed for managing brain-dead organ donors (BDODs) to improve their organ function and the organ procurement rate. Therefore, we aimed to evaluate the previously recommended threshold for red blood cell transfusion in BDODs. Medical records of BDODs were retrospectively reviewed from January 2012 to December 2021. We enrolled BDODs who stayed for more than 24 hours at an hospital organ procurement organization. We analyzed their organ function and the rate of organ procurement according to the hemoglobin concentration. A total of 111 BDODs were enrolled and divided into the following 2 groups hemoglobin (Hb)â
≥â
10 g/dL (45.0 %) and Hbâ
<â
10 g/dL (55.0 %). There were no significant differences between the groups in the total bilirubin, creatinine, arterial blood lactate, and the rate of organ procurement. A correlation analysis did not reveal any association between the hemoglobin concentration and organ function of the BDODs. Hemoglobin concentration of 10 g/dL cannot be considered a threshold for red blood cell transfusion. Furthermore, organ function is not correlated with a hemoglobin concentrationâ
>â
7 g/dL. Restrictive transfusion strategy is appropriate for BDOD management.
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1
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
/
Transfusão de Eritrócitos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article