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The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging.
Hernandez Cordero, Ana I; Yang, Chen Xi; Li, Xuan; Yang, Julia; Shaipanich, Tawimas; MacIsaac, Julie L; Lin, David T S; Kobor, Michael S; Horvath, Steve; Man, Shu Fan Paul; Sin, Don D; Leung, Janice M.
Afiliação
  • Hernandez Cordero AI; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
  • Yang CX; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
  • Li X; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
  • Yang J; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
  • Shaipanich T; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
  • MacIsaac JL; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
  • Lin DTS; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
  • Kobor MS; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
  • Horvath S; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
  • Man SFP; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
  • Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
  • Leung JM; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Biomedicines ; 10(12)2022 Dec 01.
Article em En | MEDLINE | ID: mdl-36551848
One key feature of Chronic Obstructive Pulmonary Disease (COPD) is that its prevalence increases exponentially with age. DNA methylation clocks have become powerful biomarkers to detect accelerated aging in a variety of diseases and can help prognose outcomes in severe COPD. This study investigated which DNA methylation clock could best reflect airway epigenetic age when used in more accessible blood samples. Our analyses showed that out of six DNA methylation clocks investigated, DNAmGrimAge demonstrated the strongest correlation and the smallest difference between the airway epithelium and blood. Our findings suggests that blood DNAmGrimAge accurately reflects airway epigenetic age of individuals and that its elevation is highly associated with COPD.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article