Prediction of Drug-Drug-Gene Interaction Scenarios of (<i>E</i>)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling.

Prediction of Drug-Drug-Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling.

Kovar, Christina; Kovar, Lukas; Rüdesheim, Simeon; Selzer, Dominik; Ganchev, Boian; Kröner, Patrick; Igel, Svitlana; Kerb, Reinhold; Schaeffeler, Elke; Mürdter, Thomas E; Schwab, Matthias; Lehr, Thorsten.

Afiliação

Kovar C; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Kovar L; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Rüdesheim S; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Selzer D; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Ganchev B; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Kröner P; Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Igel S; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Kerb R; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Mürdter TE; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Lehr T; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.

Pharmaceutics ; 14(12)2022 Nov 25.

Article em En | MEDLINE | ID: mdl-36559098

Palavras-chave

(E)-clomiphene; clomiphene; cytochrome P450 2D6 (CYP2D6) polymorphisms; drugdrug interactions (DDIs); drugdruggene interactions (DDGIs); druggene interactions (DGIs); pharmacokinetics; physiologically based pharmacokinetic (PBPK) modeling

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article