Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy.

Wang, Wen-Chien; Sayedahmed, Ekramy E; Mittal, Suresh K

Wang, Wen-Chien; Sayedahmed, Ekramy E; Mittal, Suresh K.

Afiliação

Wang WC; Department of Comparative Pathobiology, Purdue Institute of Immunology, Inflammation and Infectious Disease, Purdue University Center for Cancer Research, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Sayedahmed EE; Department of Comparative Pathobiology, Purdue Institute of Immunology, Inflammation and Infectious Disease, Purdue University Center for Cancer Research, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Mittal SK; Department of Comparative Pathobiology, Purdue Institute of Immunology, Inflammation and Infectious Disease, Purdue University Center for Cancer Research, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.

Viruses ; 14(12)2022 12 06.

Article em En | MEDLINE | ID: mdl-36560730

Assuntos

Infecções por Adenoviridae; Adenoviridae; Humanos; Adenoviridae/genética; Terapia Genética; Vacinação; Transgenes; Vetores Genéticos/genética; Imunidade Inata

Palavras-chave

adenoviral gene therapy; adenoviral immunity; adenoviral innate immunity; adenoviral vector immunity; adenoviral vector vaccine; adenovirus capsid; adenovirus tropism; blood factor; circumvention of preexisting vector immunity; hepatic toxicity; preexisting immunity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenoviridae / Infecções por Adenoviridae Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenoviridae / Infecções por Adenoviridae Idioma: En Ano de publicação: 2022 Tipo de documento: Article