Deep learning based on preoperative magnetic resonance (MR) images improves the predictive power of survival models in primary spinal cord astrocytomas.
Neuro Oncol
; 25(6): 1157-1165, 2023 06 02.
Article
em En
| MEDLINE
| ID: mdl-36562243
ABSTRACT
BACKGROUND:
Prognostic models for spinal cord astrocytoma patients are lacking due to the low incidence of the disease. Here, we aim to develop a fully automated deep learning (DL) pipeline for stratified overall survival (OS) prediction based on preoperative MR images.METHODS:
A total of 587 patients diagnosed with intramedullary tumors were retrospectively enrolled in our hospital to develop an automated pipeline for tumor segmentation and OS prediction. The automated pipeline included a T2WI-based tumor segmentation model and 3 cascaded binary OS prediction models (1-year, 3-year, and 5-year models). For the tumor segmentation model, 439 cases of intramedullary tumors were used to model training and testing using a transfer learning strategy. A total of 138 patients diagnosed with astrocytomas were included to train and test the OS prediction models via 10 × 10-fold cross-validation using CNNs.RESULTS:
The dice of the tumor segmentation model with the test set was 0.852. The results indicated that the best input of OS prediction models was a combination of T2W and T1C images and the tumor mask. The 1-year, 3-year, and 5-year automated OS prediction models achieved accuracies of 86.0%, 84.0%, and 88.0% and AUCs of 0.881 (95% CI 0.839-0.918), 0.862 (95% CI 0.827-0.901), and 0.905 (95% CI 0.867-0.942), respectively. The automated DL pipeline achieved 4-class OS prediction (<1 year, 1-3 years, 3-5 years, and >5 years) with 75.3% accuracy.CONCLUSIONS:
We proposed an automated DL pipeline for segmenting spinal cord astrocytomas and stratifying OS based on preoperative MR images.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Astrocitoma
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Neoplasias da Medula Espinal
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Aprendizado Profundo
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article