Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial.

Hohmann, Nicolas; Schröder, Fabian; Moreira, Bernardo; Teng, Haidong; Burhenne, Jürgen; Bruckner, Thomas; Mueller, Sebastian; Haefeli, Walter E; Seitz, Helmut K

Hohmann, Nicolas; Schröder, Fabian; Moreira, Bernardo; Teng, Haidong; Burhenne, Jürgen; Bruckner, Thomas; Mueller, Sebastian; Haefeli, Walter E; Seitz, Helmut K.

Afiliação

Hohmann N; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg 69120, Germany.
Schröder F; Centre of Alcohol Research (CAR) University of Heidelberg, Germany, and Department of Medicine, Salem Medical Centre, Heidelberg 69121, Germany.
Moreira B; Centre of Alcohol Research (CAR) University of Heidelberg, Germany, and Department of Medicine, Salem Medical Centre, Heidelberg 69121, Germany.
Teng H; Centre of Alcohol Research (CAR) University of Heidelberg, Germany, and Department of Medicine, Salem Medical Centre, Heidelberg 69121, Germany.
Burhenne J; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg 69120, Germany.
Bruckner T; Institute for Medical Biometry and Informatics, Heidelberg University, Heidelberg 69120, Germany.
Mueller S; Centre of Alcohol Research (CAR) University of Heidelberg, Germany, and Department of Medicine, Salem Medical Centre, Heidelberg 69121, Germany.
Haefeli WE; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg 69120, Germany.
Seitz HK; Centre of Alcohol Research (CAR) University of Heidelberg, Germany, and Department of Medicine, Salem Medical Centre, Heidelberg 69121, Germany.

Alcohol Alcohol ; 58(2): 134-141, 2023 Mar 10.

Article em En | MEDLINE | ID: mdl-36562601

Assuntos

Alcoolismo; Fígado Gorduroso; Hepatopatias Alcoólicas; Animais; Humanos; Clormetiazol/metabolismo; Clormetiazol/farmacologia; Clorazepato Dipotássico; Citocromo P-450 CYP2E1; Alcoolismo/metabolismo; Espécies Reativas de Oxigênio; Fígado; Hepatopatias Alcoólicas/metabolismo; Etanol/farmacologia; Transaminases/metabolismo; Transaminases/farmacologia; Alanina Transaminase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcoolismo / Fígado Gorduroso / Hepatopatias Alcoólicas Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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