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Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.
Pei, Fei; Yao, Ren-Qi; Ren, Chao; Bahrami, Soheyl; Billiar, Timothy R; Chaudry, Irshad H; Chen, De-Chang; Chen, Xu-Lin; Cui, Na; Fang, Xiang-Ming; Kang, Yan; Li, Wei-Qin; Li, Wen-Xiong; Liang, Hua-Ping; Lin, Hong-Yuan; Liu, Ke-Xuan; Lu, Ben; Lu, Zhong-Qiu; Maegele, Marc; Peng, Tian-Qing; Shang, You; Su, Lei; Sun, Bing-Wei; Wang, Chang-Song; Wang, Jian; Wang, Jiang-Huai; Wang, Ping; Xie, Jian-Feng; Xie, Li-Xin; Zhang, Li-Na; Zingarelli, Basilia; Guan, Xiang-Dong; Wu, Jian-Feng; Yao, Yong-Ming.
Afiliação
  • Pei F; Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Er Road, Yuexiu District, Guangzhou, 510080, Guangdong, China.
  • Yao RQ; Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
  • Ren C; Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
  • Bahrami S; Translational Medicine Research Center, Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
  • Billiar TR; Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology, 1200, Vienna, Austria.
  • Chaudry IH; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
  • Chen DC; Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
  • Chen XL; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, 200025, China.
  • Cui N; Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  • Fang XM; Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
  • Kang Y; Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 31003, China.
  • Li WQ; Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.
  • Li WX; Department of Critical Care Medicine, General Hospital of Eastern Theater Command of Chinese PLA, Nanjing, 210002, China.
  • Liang HP; Department of Surgical Intensive Critical Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
  • Lin HY; State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.
  • Liu KX; Department of Critical Care Medicine, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, 100048, China.
  • Lu B; Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Lu ZQ; Department of Critical Care Medicine and Hematology, the Third Xiangya Hospital, Central South University, Changsha, 410000, China.
  • Maegele M; Emergency Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • Peng TQ; Department of Traumatology and Orthopedic Surgery, University Witten-Herdecke, 51109, Cologne, Germany.
  • Shang Y; Critical Illness Research, Lawson Health Research Institute, London Health Sciences Centre, London, ON, N6A 4G4, Canada.
  • Su L; Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Sun BW; Department of Intensive Care Unit, General Hospital of Southern Theater Command of Chinese PLA, Guangzhou, 510030, China.
  • Wang CS; Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215002, China.
  • Wang J; Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Wang JH; Children's Hospital of Soochow University, Pediatric Research Institute of Soochow University, Suzhou, 215123, China.
  • Wang P; Department of Academic Surgery, University College Cork, Cork University Hospital, Cork, T12 E8YV, Ireland.
  • Xie JF; Center for Immunology and Inflammation, the Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 11030, USA.
  • Xie LX; Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
  • Zhang LN; Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
  • Zingarelli B; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Guan XD; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 41073, USA.
  • Wu JF; Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Er Road, Yuexiu District, Guangzhou, 510080, Guangdong, China. guanxd@mail.sysu.edu.cn.
  • Yao YM; Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Er Road, Yuexiu District, Guangzhou, 510080, Guangdong, China. wujianf@mail.sysu.edu.cn.
Mil Med Res ; 9(1): 74, 2022 12 26.
Article em En | MEDLINE | ID: mdl-36567402
ABSTRACT
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Imunossupressão / Sepse Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Imunossupressão / Sepse Idioma: En Ano de publicação: 2022 Tipo de documento: Article